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BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. It also acts as a potent casein kinase 2α inhibitor with an IC50 of ~10 μM. This compound is intended for research use only.
Highly selective and potent PAS kinase inhibitor
Potent casein kinase 2α inhibitor
Reduces SREBP activity without affecting cell morphology or growth rate
Decreases insulin resistance, hepatic and serum TAG, and serum glucose in animal models
Suppresses expression of SREBP-1c target genes
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Metformin (1 1-Dimethylbiguanide) a widely used drug for treatment of type 2 diabetes activates AMP-activated protein kinase (AMPK) in hepatocytes Metformin promotes mitophagy in mononuclear cells Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
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Biotin-naphthylamine is a biotinylated biochemical assay reagent used as a substrate for ascorbate peroxidase 2 (APEX2). It serves as a labeling probe for DNA and RNA in biochemical and molecular biology applications.
Biotinylated substrate for APEX2, enabling enzymatic labeling.
Suitable for DNA and RNA labeling applications.
High purity (98.3%) for reliable assay performance.
Molecular weight 426.57 g/mol; formula C23H30N4O2S.
Store protected from light and under nitrogen; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More